John P. Moore; Paul A. Offit. SARS-CoV-2 Vaccines and the Growing Threat of Viral Variants. JAMA 2021 online
These “escape mutations” typically arise when the virus is put under selective pressure by antibodies that limit but do not eliminate viral replication. Under these conditions, the virus might then find a way to escape this pressure and restore its ability to reproduce more efficiently. The scenario of virus evolution in the face of suboptimal immunity is one reason extending the interval between the first and second dose of a SARS-CoV-2 vaccine might be problematic …
28 stycznia 2021