Thomas F Lüscher. Lumpers and splitters: the bumpy road to precision medicine. Eur Heart J 2019;40:292–3296 (dostępny pełen tekst)
Although a reduced pump function can occur after a myocardial infarction, due to cardiomyopathies caused by a number of gene variants, due to storage diseases or deposition of false-folded proteins, due to excessive alcohol consumption or triggered by chemotherapeutic agents. the pioneering heart failure trials lumped all such patients together to evaluate the effectiveness of angiotensin converting enzyme (ACE)-inhibition. The success of this approach led to later trials using beta-blockers, such as bisoprolol, carvedilol, or metoprolol …
21 października 2019