Skuteczność i bezpieczeństwo dalszego obniżania LDL cholesterolu u pacjentów z wyjściowo bardzo niskimi stężeniami: meta-analiza

Marc S. Sabatine i wsp. Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels.  AMeta-analysis. JAMA Cardiol. Published online

Conclusions and Relevance:  There is a consistent relative risk reduction in major vascular events per change in LDL-C in patient populations starting as low as a median of 1.6 mmol/L (63 mg/dL) and achieving levels as low as a median of 0.5 mmol/L (21 mg/dL), with no observed offsetting adverse effects. These data suggest further lowering of LDL-C beyond the lowest current targets would further reduce cardiovascular risk.

JAMA Cardiology, 1 sierpnia 2018