Salim Yusuf. A 35-year journey to evidence-based medicine: a personal story. Eur Heart J (2015) online first (dostępny pełen tekst ang.)
In long-term secondary prevention, four simple drugs (antiplatelet drugs, β-blockers, ACE-inhibitors, and statins) along with a healthy lifestyle which included avoidance of tobacco, a healthy diet and moderate exercise could reduce subsequent deaths and reinfarction by over 80–90% (Table 1) …
Table 1
Potential cumulative impact of four simple secondary-prevention treatments
| Relative-risk reduction (%) | 2-year event rate (%) | |
| None | 8 | |
| Aspirin | 25 | 6 |
| β-Blockers | 25 | 4.5 |
| Lipid lowering (by 1.5 mmol) | 30 | 3.0 |
| ACE inhibitors | 25 | 2.3 |
European Heart Journal, 19 listopada 2015