Wpływ leków rekomendowanych w wytycznych na wskaźniki śmiertelności u osób z wieloma chorobami przewlekłymi – populacyjne badanie kohortowe

Mary E Tinetti i wsp. Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. BMJ 2015 online (dostępny pełen tekst ang.)

What this study adds:

The beneficial effects on survival of β blockers, calcium channel blockers, renin angiotensin system blockers, statins, and warfarin are comparable to those
reported in randomized controlled trials but vary for β blockers and warfarin according to coexisting conditions.

Clopidogrel, metformin, and serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors were not associated with survival benefit.

Determining effects in combinations of coexisting conditions may guide prescribing in people with multiple chronic conditions.

BMJ, 2 października 2015