Złożony inhibitor neprylizyny i receptora angiotensyny II w niewydolności serca – badanie PARADIGM-HF

PARADIGM-HF Investigators and Committees. Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure , LINK: N Engl online (dostępny pełen tekst)

The trial was stopped early, according to prespecified rules, after a median follow-up of 27 months, because the boundary for an overwhelming benefit with LCZ696 had been crossed. At the time of study closure, the primary outcome had occurred in 914 patients (21.8%) in the LCZ696 group and 1117 patients (26.5%) in the enalapril group (hazard ratio in the LCZ696 group, 0.80; 95% confidence interval [CI], 0.73 to 0.87; P<0.001).

LCZ696 was superior to enalapril in reducing the risks of death and of hospitalization for heart failure.

Opracowane na podstawie: NEJM / 30 sierpnia 2014