The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants, LINK:The Lancet, Early Online Publication
46% of the excess risk of BMI for coronary heart disease and 76% for stroke is mediated by these factors. Blood pressure was the most important mediator, accounting for 31% of the excess risk for coronary heart disease and 65% for stroke.
Interventions that reduce high blood pressure, cholesterol, and glucose might address about half of excess risk of coronary heart disease and three-quarters of excess risk of stroke associated with…
Opracowane na podstawie: Lancet / 22 listopada 201